In 1670, English settlers who arrived on Daniel Island from Barbados found the Etiwan inhabiting the area.
By 1707, The Etiwan had migrated to the Goose Creek area. Reverend Francis Le Jau, described the Etiwans as having a deep chestnut color, hair black and straight, their eyes black and sparkling, with little or no hair on their chins, and well limbed and featured.
During the 1715 Yemassee War, Etiwan were among the 100 or so free Indians that fought with the English.
By 1750, the Etiwan were subject to hostile Indian raiding parties from the North who sought to capture them and trade them as slaves to the Spanish.
Last historical reference was in 1751. The Etiwan were mentioned as one of the small tribes for which South Carolina's colonial government made peace with the Iroquois.