| Central Carolina Technical College | Multiple Locations |
| Darlington County School District | Multiple Locations |
| Emmanuel Christian School | Hartsville |
| Governor's School for Science and Mathematics | Hartsville |
| Pee Dee Electric Cooperative | Darlington |
| City of Darlington | Darlington | City of Hartsville | Hartsville |
| Darlington County | Multiple Locations |
| Georgia-Pacific | Darlington |
| JBE | Hartsville |
| Nucor Steel | Darlington |
| Sonoco | Hartsville |
| Stingray Powerboats | Hartsville |
| CareSouth Carolina | Multiple Locations |
| Carolina Pines Regional Medical Center - part of ScionHealth | Hartsville |
| Palmetto Goodwill | Hartsville |
| Spectrum | Hartsville |