Four counties created by the Lords Proprietors:
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1682 | Berkeley | Area around Charleston; combined with Colleton County in 1769 to form Charleston District; separated from Charleston in 1882
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| Colleton | Area south of Berkeley County to the Combahee River; combined with Berkeley County in 1769 to form Charleston District; separated from Charleston in 1880
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| Craven | Area north of Berkeley County to the North Carolina border
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1686 | Granville | Area south of Colleton County to the Georgia border
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Seven judicial districts created by South Carolina's colonial General Assembly:
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1769 | Beaufort | From Granville County (see above)
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| Charleston | From Berkeley and Colleton Counties (see above)
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| Georgetown | From Craven County (see above)
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| Cheraws | Area northwest of Georgetown
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| Camden | Large area west of Cheraws District
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| Ninety Six | Area northwest of Camden District
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| Orangeburg | Area southwest of Camden District
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Forty counties created after the American Revolution:
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1785 | Orange | From Orangeburg District; abolished in 1791
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| Lewisburg | From Orangeburg District; early version of Lexington County; abolished in 1791
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| Winton | From Orangeburg District; early version of Barnwell County; renamed in 1800
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| Kingston | From Georgetown District with modern Horry County boundaries designated; renamed Horry District in 1801
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| Liberty | From Georgetown District; renamed as Marion County in 1800
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| Williamsburg | From Georgetown District; became inactive quickly; revived in 1804
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| Winyah | From Georgetown District; renamed as Georgetown County in 1800
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| Chesterfield | From Cheraws District
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| Darlington | From Cheraws District
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| Marlboro | From Cheraws District
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| Chester | From Camden District
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| Claremont | From Camden District
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| Clarendon | From Camden District; absorbed by Sumter District in 1800; then recreated from Sumter about 1855
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| Fairfield | From Camden District
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| Lancaster | From Camden District
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| Richland | From Camden District
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| York | From Camden District
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| Abbeville | From Ninety Six District
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| Edgefield | From Ninety Six District
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| Laurens | From Ninety Six District
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| Newberry | From Ninety Six District
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| Spartanburg | From Ninety Six District
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| Union | From Ninety Six District
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1786 | Greenville | From Cherokee lands
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1789 | Pendleton | From Cherokee lands
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1791 | Kershaw | From parts of Claremont, Fairfield, Lancaster, and Richland
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| Salem | From parts of Claremont and Clarendon
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1800 | Barnwell | From Orangeburg
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| Georgetown | From Georgetown; later version of Winyah County
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| Marion | From Georgetown; later version of Liberty
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| Sumter | From Claremont, Clarendon, and Salem
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1801 | Horry | From Georgetown; later version of Kingston County
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1804 | Lexington | From Orangeburg; later version of Lewisburg County
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1826 | Anderson | From Pendleton
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| Pickens | From Pendleton
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1868 | | The Constitution of 1868 declared "the Judicial Districts shall hearafter be designated as Counties"
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| Oconee | From western part of Pickens
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1871 | Aiken | From Barnwell, Edgefield, Lexington, and Orangeburg
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1878 | Hampton | From Beaufort
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1888 | Florence | From Clarendon, Darlington, Marion, Williamsburg
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1895 | Saluda | From Edgefield
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1897 | Bamberg | From Barnwell
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| Cherokee | From Spartanburg, Union, and York
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| Dorchester | From Berkeley and Colleton
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| Greenwood | From Abbeville and Edgefield
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1902 | Lee | From Darlington, Kershaw, and Sumter |
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1908 | Calhoun | From Lexington and Orangeburg
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1910 | Dillon | From Marlboro
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1912 | Jasper | From Beaufort and Hampton
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1916 | McCormick | From Abbeville, Edgefield, and Greenwood
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1919 | Allendale | From Barnwell and Hampton
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